Lab-on-chip devices provide the ability of performing the complete cycle of biological reaction on a nano scale volume of the sample solution, resulting in reliable and rapid analysis. State-of-the-art nano/microfabrication facilities we can fabricate Lab-on-Chips that integrate nano and micro scale features in one single fluidic device. Such integrated devices are capable of capturing biological substances of different dimension varying from cell, bacteria to DNA and performing direct analysis. We propose a novel lab-on-chip device with embedded nanostructured sensors for point-of-care diagnostics. The proposed device is integrated with a dielectrophoretic assisted sample delivery system for efficient concentration of the analytes from the sample solution. The ability to dynamically alter the flow through an automated flow actuation system offers the advantage of multiple steps buffer exchange and sample processing.